VERY HIGH CELL DENSITY PERFUSION PROCESS IN SMALL-SCALE BIOREACTOR PERFUSION SYSTEM
Hubert Schwarz (PhD student at AdBIOPRO) has now published his article about very high cell density perfusion process in small-scale bioreactor perfusion system in J. of Biotechnology. The article is available at the link below (free of access until Feb 18, 2020).
Article : authors.elsevier.com
Highlights:
- Cell densities of HEK293 cells and CHO cells maintained at 80 and 100 x 10^6 cells/mL
- Novel small-scale perfusion bioreactor system for animal/human cells with working volumes < 250 mL
- Very low cell specific perfusion rate down to 10 pL/cell/day
- HEK293 cell expressing Erythropoietin cultured in high cell density perfusion process more than 75 days